Pathology EMQ template.

Name:

Candidate number:

Theme: Myeloproliferative Disease

 

OPTION LIST

 

A	Acute myeloid leukaemia	I	Myelodysplasia
B	Anaemia of chronic disease	J	Parvovirus B19
C	Chronic myeloid leukaemia	K	Polycythaemia vera
D	Colon cancer	L	Thrombosis
E	Disseminated intravascular coagulation	M
F	Haemoglobin H disease	N
G	Haemorrhagic stroke	O
H	JAK 2	P

 

 

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

 

1. What secondary disease are patients with myeloproliferative disease most at risk of developing?

 

 

2. 66-year old Mr GB is admitted to hospital with a badly sprained wrist following a minor road traffic accident. He admits that he failed an eye test two weeks ago, has been feeling dizzy and probably should not have been driving. His son, who is accompanying him, says that Mr GB looks more flushed than when he last saw him three months ago. On examination you detect an abdominal mass. His FBC shows Hb=19.2, platelets=502. What is the most likely diagnosis?

 

 

3. Mr GB is given aspirin. What is he at risk of with a platelet count of 502x10⁹?

 

 

4. With what is the chromosomal translocation (9;22) strongly associated?

 

 

5. A 60 year old man visits his GP for a new patient medical. He says he is in fine health and has in fact lost weight. He admits to feeling a little tired. Routine blood tests reveal that he is mildly anaemic and has a white cell count of 100x10⁹, composed mainly of neutrophils. The GP, a former haematologist, requests a blood film which shows that these are mature neutrophils. What is the most likely diagnosis?

 

 

 

ANSWERS

1. A

2. K

3. L

4. C

5. C